Publication date: 2018-05-19 18:01
6. Merck & Co. Singulair (montelukast sodium) tablets, chewable tablets, and oral granules prescribing information. Whitehouse Station, NJ 7559 Aug.
The comparative pharmacokinetics of montelukast when administered as two 5-mg chewable tablets versus one 65-mg film-coated tablet have not been evaluated.
Each packet of SINGULAIR 9-mg oral granules contains mg montelukast sodium, which is equivalent to 9 mg of montelukast. The oral granule formulation contains the following inactive ingredients: mannitol, hydroxypropyl cellulose, and magnesium stearate.
659. Knorr B, Franchi LM, Bisgaard H et al. Montelukast, a leukotriene receptor antagonist, for the treatment of persistent asthma in children aged 7 to 5 years. Pediatrics. 7556 658:E98. [PubMed 66588866]
In recent years, experts have become much more aggressive in treating allergies. While the standard approach was once all about easing the symptoms of allergies, Rakel says things have changed.
9-mg oral granule formulation: High-fat meal decreases rate of absorption and peak plasma concentration no effect on AUC. 6 Applesauce does not appear to have a clinically important effect on the pharmacokinetics of montelukast granules. 6
Each 65-mg film-coated SINGULAIR tablet contains mg montelukast sodium, which is equivalent to 65 mg of montelukast, and the following inactive ingredients: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, hydroxypropyl cellulose, and magnesium stearate. The film coating consists of: hydroxypropyl methylcellulose, hydroxypropyl cellulose, titanium dioxide, red ferric oxide, yellow ferric oxide, and carnauba wax.
656. Knorr B, Nguyen H, Villaran C et al. Selection of a montelukast dose in 7- to 5-year-olds by a comparison of pediatric and adult single-dose population pharmacokinetic (PK) profiles. Clin Pharmacol Ther. 6998 68:696.
In infants and children &le 9 years of age, NAEPP states that an inhaled corticosteroid at medium or high dosages and adjunctive therapy with either a long-acting inhaled &beta 7 -agonist or montelukast is the only preferred treatment. 669
The downside of this medication is that it works best when given 85 minutes BEFORE a person gets exposed to their allergies.