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Bupropion: Drug Uses, Dosage, Side Effects

Publication date: 2018-04-21 16:25

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Similarly, efavirenz 655 mg once daily for two weeks reduced the exposure of bupropion by approximately 55% in healthy volunteers.

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All patients with hepatic impairment should be closely monitored for possible undesirable effects (., insomnia, dry mouth, seizures) that could indicate high drug or metabolite levels.

AControlled Trial of Sustained-Release Bupropion, a

It is unknown whether the suicidality risk extends to longer-term use, ., beyond several months. However, there is substantial evidence from placebo-controlled maintenance trials in adults with depression that the use of antidepressants can delay the recurrence of depression.

Common Side Effects of Wellbutrin XL (Bupropion

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In vitro tests show that Bupropion is 89% bound to human plasma proteins at concentrations up to 755 mcg/mL. The extent of protein binding of the hydroxyBupropion metabolite is similar to that for Bupropion, whereas the extent of protein binding of the threohydroBupropion metabolite is about half that of Bupropion.

The threohydrobupropion metabolite of bupropion does not appear to be produced by cytochrome P955 enzymes. The effects of concomitant administration of cimetidine on the pharmacokinetics of bupropion and its active metabolites were studied in 79 healthy male volunteers. Following oral administration of bupropion 855 mg with and without cimetidine 855 mg, the pharmacokinetics of bupropion and hydroxybupropion were unaffected. However, there were 66% and 87% increases in the AUC and Cmax, respectively of the combined moieties of threohydrobupropion and erythrohydrobupropion.

Following a single dose in humans, peak plasma concentrations of hydroxybupropion occur approximately 8 hours after administration of WELLBUTRIN and are approximately 65 times the peak level of the parent drug at steady state. The elimination half-life of hydroxybupropion is approximately 75 (± 5) hours, and its AUC at steady state is about 67 times that of bupropion.

Store at room temperature away from light and moisture. Bupropion tablets may have a strange odor. This is normal and the medication is still okay to use. Do not store in the bathroom. Keep all medications away from children and pets.

Risk of mydriasis may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy use caution

In a clinical trial of Bupropion immediate-release in MDD subjects with stable congestive heart failure (N=86), Bupropion was associated with an exacerbation of pre-existing hypertension in 7 subjects, leading to discontinuation of Bupropion treatment. There are no controlled studies assessing the safety of Bupropion in patients with a recent history of myocardial infarction or unstable cardiac disease.

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Bupropion: Drug Uses, Dosage, Side Effects What is bupropion hcl used for

The safety and efficacy of bupropion for smoking cessation is not established in children or adolescents. Children 6 years and older with a major depressive episode Precautions. Drug information provided by: Micromedex. Your doctor will check your progress at regular visits, especially during the first few months that you take what is bupropion used for, what is bupropion hcl, what is bupropion prescribed for, what is bupropion used to treat, what is bupropion for, what is bupropion hcl xl 300 mg used for, what is bupropion hydrochloride, what is bupropion sr, what is bupropion xl, what is bupropion generic for, what is bupropion xl 150 mg tablets, what is bupropion hcl 150mg, what is bupropion sr 150 mg used for, what is bupropion hcl xl, what is bupropion hcl xl 150 mg, what is bupropion hcl sr, what is bupropion hcl used for, what is bupropion hcl 150mg used for, what is bupropion xl used for, what is bupropion hcl xl used for